62-years old man was admitted in coronary care unit with ST-segment myocardial infarction of anteroseptal and lateral walls. Emergency coronarography showed occlusion of LAD, Cx on distal segment showed significant stenosis (80%), RCA in middle segment showed non significant plaque. Coronarography was followed by PCI procedure of LAD and implantation of two stents, on proximal and middle segment of LAD. Result was successful. Patient was stable afterwards, until third day, when he felt chest pain. ECG showed ST-segment elevation in anteroseptal and lateral leads. Emergency coronarography showed occlusion of proximal LAD, in proximal stent with new occurring thrombus. Balloon dilatation of in-stent segment was done, which was followed by opening of LAD. Crossing middle to distal segment showed significant stenosis, which was followed by balloon dilatation. Finally balloon dilatation with NC balloon was done. The result was successful. Afterward he was stable. Seven days after procedure he was released home with recommendation to use clopidogrel 150 mg and aspirin 100 mg. Second day after release from hospital, he felt again chest pain, and was admitted in coronary care unit with anteroseptal and lateral ST-segment elevation on ECG. Emergency coronarography showed subostial LAD occlusion. Primary PCI LAD was done with stenting of ostial LAD with bare metal stent. Result was successful. Thrombocyte aggregation tests were done (aggregation test with colagen, ADP and ristocetin). Results showed that thrombocyte aggregation in ADP test was within referent values, which points absence of thrombocyte inhibition by clopidogrel. Considering clopidogrel resistance, he was given ticagrelor. Further he was hemodynamic stable without chest pain. He was released home and doing well thereafter. (