CC Cardiol Croat Cardiologia Croatica Cardiol. Croat. 1848-543X 1848-5448 Croatian Cardiac Society CC_2014_9_3-4_111 10.15836/ccar.2014.111 Extended Abstract Contributing factors in heart failure development-results from CRO-HF Registry GlavasDuska1MilicicDavor2PolicStojan1Jurcevic ZidarBranka3NovakKatarina1 University Hospital Centre Split, Split, Croatia University Hospital Centre Zagreb, Zagreb, Croatia Public Health Institute of Split and Dalmatian County, Split, Croatia Correspondence to Duska Glavas, Klinicki bolnicki centar Split, Spinciceva 1, HR-21000 Split, Croatia; Phone: +385-21-556-111; E-mail: duskag@net.hr 032014 032014 9 3-4 111 111 Croatian Cardiac Society 2014 Croatian Cardiac Society KEYWORDS: heart failurerisk factorsCroatia

Introduction: There are many causes of heart failure (HF), and these vary in different populations. The aim of the study was to analyse the contributing factors in heart failure development.

Methods: We analyzed the results from CRO-HF Registry (1, 2). This on-line registry was established in 2005.

Results: A total of 2203 in-hospital HF patients from CROHF Registry were analyzed: 1,028 (46.7%) females (F) and 1,175 (53.3%) males (M); median age was 76 years. Preserved left ventricular systolic function (LVEF 50%) was recorded in 37.8% patients.

History of arterial hypertension was recorded in 67.5% patients, diabetes mellitus in 34.4%, myocardial infarction in 22.7%, renal insufficiency in 19.2%, chronic obstructive pulmonary disease (COPD) in 17.3%, and cerebrovascular disease in 16.5% patients. Atrial fibrillation or undulation was noted in 53.7% patients. Active smoking habit was recorded in 11.1% patients and 15.6% patients were former smokers.

Overweight was recorded in 46.3% patients and obesity in 25%.

The frequent precipitating factors of HF were arterial hypertension (55.5% patients), arrhythmias (51.3%), valvular heart disease (32.8%), acute coronary sindrome (19.7%), and infections (19.6%).

Lower levels of haemoglobin was recorded in 51.9% patients, higher levels of creatinine in 46.8%, ALT in 29.8%, cholesterol in 32.7%, tryglicerides in 31.9%, uric acid in 79.3% and hyperglycaemia in 99.8% patients. Females had higher values of ALT (F-33%, M-27%, P=0.012), cholesterol (F-36.8%, M-29.1%, P=0.009), tryglicerides (F-36.1%, M- 28.3%, P=0.014), and uric acid (F-82.9%, M-76.4%, P=0.007). Opposite to expectation, males had lower haemoglobin levels (M-58%, F-44.8%, P 0.001).

In-hospital mortality rate was 13.8%.

Conclusion: The considerable underlaing diseases of HF were hypertension, diabetes mellitus, myocardial infarction, renal insufficiency and COPD. one-third of HF patients were smokers (active or former) and two-third of them were overweight or obese. Hypertension was the most important “trigger” of our HF patients, close to arrhythmia, ACS, and infections. (1-2)

Literature PolicSZaputovicLMilicicDGlavasD. Croatian Heart Failure Registry: intial results — part II. Lijec Vjesn. 2007;129 Suppl 4:34. PolicSGlavasD. Some specific features of identification and treatment of heart failure in the Republic of Croatia. Cardiol Croat. 2011;6(11):286–8.